Generic Viagra Drug Information

viagrageneric25mg, 50mg, 100mg Generic Viagra Contraindications Risks References!

Discover how Generic Viagra (sildenafil) drug therapy works

Viagra-sildenafil-100mgRemember that no medicine is for everyone. If you use nitrate drugs, often used to control chest pain (also known as angina), don’t take Sildenafil Citrate (The active ingredient in Viagra brand and Generic Viagra).

This risk combination could cause your blood pressure to drop to an unsafe or life-threatening level. Be sure to ask your doctor if your heart is healthy enough for sexual activity.

For most patients, the recommended dosage is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, sildenafil citrate (generic Viagra) may be taken anywhere from 4 hours to 0.5 hour before sexual activity.

Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

The Following Risks Factors are Associated with Increased Plasma Levels of Sildenafil:

Age >65 (40% increase in AUC), hepatic impairment (e.g., cirrhosis, 80%), severe renal impairment (creatinine clearance <30 ml/min, 100%), and concomitant use of potent cytochrome P450 3A4 inhibitors (erythromycin, ketoconazole, itraconazole, 200%, saquinavir 210%). Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.

Given the extent of the interaction with patients receiving concomitant therapy with ritonavir, it is recommended not to exceed a maximum single dose of 25 mg of sildenafil citrate in a 48 hour period.

Sildenafil citrate was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated.

Recommended Storage: Store at controlled room temperature, 15-30°C (59-86°F).

Mechanism of Action:

The physiologic mechanism of genital erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

Sildenafil citrate has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Caverta (generic Viagra) at recommended doses has no effect in the absence of sexual stimulation.

Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (>80-fold for PDE1, >1000-fold for PDE2, PDE3, and PDE4). The approximately 4000-fold selectivity for PDE5 versus PDE3 is important because that PDE is involved in control of cardiac contractility.

Sildenafil citrate is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina; this lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels.

In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.

Generic Viagra Contraindications References:

Consistent with its known effects on the nitric oxide/cGMP pathway, sildenafil citrate was shown to potentiate the hypotensive effects of nitrates and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated.

After patients have taken generic viagra sildenafil, it is unknown when nitrates, if necessary, can be safely administered. Based on the pharmacokinetic profile o a single 100 mg oral dose given to healthy normal volunteers, the plasma levels of sildenafil at 24 hours post dose are approximately 2ng/ml (compared to peak plasma levels of approximately 440 ng/ml, in the following patients: age >65, hepatic impairment (e.g, creatinine clearance <30mL/min), and concomitant use of potent cytochrome P450 3A4 inhibitors (erythromycin), plasma levels of sildenafil at 24 hours post dose have been found to be 3 to 8 times higher than those seen in healthy volunteers.

Although plasma levels of sildenafil at 24 hours post dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point. Sildenafil is contraindicated in patients with a known hypersensitivity to any component o the tablet.

GENERIC VIAGRA (Cheap and effective drug for erectile dysfunction treatment)

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Generic Viagra Availability

Treating erectile dysfunction was never possible in the past until it got to a time where companies started producing and selling what they called “brand name” drugs for ED treatment. While people who are financially buoyant continued taking the drug, others who are low-income earners could not afford the drug for long. The high price of the brand name drug made companies come up with a cheap alternative for everyone to have access to.

Erectile dysfunction has caused a lot of damages in the lives of many men. This condition has made a lot of men to suffer depression, lack of self-confidence and emotion stress. It has also shattered a lot of homes because when the man cannot satisfy his wife, the women might become unfaithful. However, with the brand version being too expensive for most people to continue with their treatment, a cheaper alternative will make more sense. Viagra works well for the treatment of erectile dysfunction but for people who are working on a low budget, keeping up with the treatment might not be possible.

Viagra Generic Availability

The availability of Viagra generic is a big plus for men who are suffering from erectile dysfunction. At last, everyone can have access to the drug anytime to restore their sex lives back to its normal state. The Viagra generic name is Sildenafil and just like the brand named drug, it is also used for the treatment of erectile dysfunction in men. Generic Viagra has been approved by the FDA for the treatment of erectile dysfunction. The drug is very active and it works just like the brand version. Before the FDA approves any generic drug for treatment, several tests will need to be performed to ascertain if the drug truly contains everything the brand named drug has.

Is there a Generic Viagra?

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Generic Viagra is available and very active for treating erectile dysfunction. The drug works just like the brand version for ED treatment. The only major difference between the brand and generic version of Viagra is the price. The generic version of Viagra is very cheap compared to the brand named drug. The Generic Viagra from India is manufactured with the best facilities and conditions in the country. The drug contains the same active ingredient as the brand named drug and both drugs produces the same effects when used to treat erectile dysfunction.

Cheap Generic Viagra

The major reason why people can get Viagra generic cheap is that companies that produce the generic drug don’t spend much on numerous advertisements, marketing and sales like the brand named drug manufacturers. That is why the prices of generic drugs are quite low. The generic name for Viagra is sildenafil, which is also the name of the main ingredient found in the generic and brand version of the drug.

Does generic Viagra work?

Generic Viagra is super active for treating erectile dysfunction. The drug works by blocking the action of the enzyme called PDE-5 which prevents blood from flowing normally to the penis. However, the quality of the drug you get is also very important as there are many counterfeit drugs out there that may destroy your efforts to restore your sex life. There are quite a lot of online pharmacy viagra generic stores selling the drug but a lot of them are not genuine. That’s why you must look for a genuine Generic Viagra online pharmacy to get quality drugs. Before you buy drugs from any online pharmacy, you must carry out proper verification to find out if the online pharmacy is genuine. There are many fraudsters online and that’s why you must be really careful. Read any Generic Viagra review you come across on the site or any other place to learn what others are saying about the online pharmacy store. However, you can read some Generic Viagra reviews online to know more about the right place to get the drug.

What are the generic Viagra names?

Generic Viagra has different names. The drug is known as Penegra, Zenegra, Kamagra, Silagra, and Edegra. Knowing all the names of the drug will make it easier for you to order the right drug for treating your condition.

When will generic Viagra be available?

The sales of Generic Viagra are very common in India. But people outside the country can order generic Viagra online. The patent of Pfizer, the manufacturer of the brand name drug “Viagra” will expire in the year 2020, but Teva Pharmaceuticals will be permitted to launch its generic version in the USA on December 11, 2017. However, you can buy generic Viagra USA from India or any other country, were the sales of the generic version of Viagra is permitted.

How to effectively take Generic Viagra

Generic Viagra tablets are taken with a glass of water on an empty stomach. You can take this drug an hour before you have sex with your partner. The drug will not cause you to have an erection on its own. Instead, you have to be stimulated sexually before it can cause you to have that rock-solid erection for penetration. On the other hand, it is not advisable to take alcohol before consuming this medication. Doing so will only reduce the effectiveness of the drug. If taken in the right way, the effect of this drug can last up to 4 or 6 hours.

Where can I buy Generic Viagra?

You can buy Generic Viagra online no matter your location. All you need to do is to look for a reputable online store with a good reputation and Generic Viagra reviews, and then place your order. Due to a number of reasons, a valid prescription will be required before you can buy Generic Levitra. This will help the doctor to determine if you are fit to take the drug or not.

A trusted online pharmacy to buy Generic Levitra

A trusted online pharmacy you can get original Generic Viagra is www.sun4rx.com. All drugs that come into this pharmacy are tested to ensure that customers always get the best. In addition, ordering drugs from this site is also very easy. Just register if you are a new user, add the quantity of drug you wish to buy and place your order right away. You can also make payments online and there are various shipping options you can choose from. Buy original Generic Viagra Canada to enjoy your sex life once again.

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No matter the shipping option you choose, www.sun4rx.com will always deliver your products safely to your doorsteps. The company has a lot of positive review as a result of their excellent services.

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