However, liver biopsy is associated with complications, such

Liver disease is the third most common cause of premature death in the UK. In England and Wales 60000 people (1 in 1000) have cirrhosis, and mortality rates have increased by 400% since the 1970s.2 Liver biopsy was historically the standard test for the diagnosis of cirrhosis for all causes of liver disease. However, liver biopsy is associated with complications, such as pain and bleeding; it is an expensive test and is less acceptable to patients because of the morbidity associated with its use.3 New diagnostic technologies such as transient elastography and acoustic radiation force impulse imaging can diagnose cirrhosis with >90% sensitivity, and mean that it is now practical and acceptable to offer testing to a greater number of people..

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