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Peyronie's genital disease, a condition of uncertain cause, is characterized by a plaque, or hard lump abnormalities, that forms on the penis. The plaque develops on the upper or lower side of the penis in layers containing erectile tissue. It begins as a localized inflammation and can develop into a hardened scar.

Cases of Peyronie's genital disease range from mild to severe. Symptoms may develop slowly or appear overnight. In severe cases, the hardened plaque reduces flexibility, causing pain and forcing the penis to curve, bend or arc during penile erection. In many cases, the genital pain decreases over time, but the bend in the penis may remain a problem, making sexual intercourse difficult. The sexual problems that result can disrupt a couple's physical and emotional relationship and lead to lowered self-esteem in the man. In a small percentage of patients with the milder form of the genital disease, inflammation may resolve without causing significant pain or permanent bending abnormalities.

Men with Peyronie's disease usually seek medical attention because of painful erections and difficulty with intercourse. Since the cause of the disease and its development are not well understood for a cure, doctors treat the disease empirically; that is, they prescribe and continue methods that seem to help. The goal of therapy is to keep the Peyronie's patient sexually active. Providing education about the disease and its course often is all that is required. No strong evidence shows that any treatment other than surgery is effective. Experts usually recommend surgery only in long-term cases in which the disease is stabilized and the deformity prevents intercourse.

Peyronies syndrome problem support treatment information resource cure references

American Foundation for Urologic Disease
1128 North Charles Street
Baltimore, MD 21201
Phone: 1-800-242-2383 or (410) 468-1800
Email: admin@afud.org
Internet: www.afud.org

National Organization for Rare Disorders
P.O. Box 8923
New Fairfield, CT 06812-8923
Phone: 1-800-999-6673
Email: orphan@nord-rdb.com
Internet: www.rarediseases.org

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